Identifying The Need Extended and controlled drug delivery systems
are very common due to their potential therapeutic benefits.
Many of these systems employ polymers that swell in
water, or have pH-dependent swelling or pH-dependent
solubility characteristics. These factors result in
formulations which show either a significant food effect
or undesirable inter-subject variability, leading to
sub-optimal in-vivo performance.
The Rubicon Research Solution RubiERTTM
is a novel controlled release technology which provides
a non-swelling dosage form with pH-independent drug
release. RubiERTTM
utilises a combination of non-swelling pH-independent
and pH-dependent polymers, which gives a release profile
that is not affected by the environmental pH conditions
of the gastrointestinal tract. Due to the constant diffusion
path length, it is possible to achieve a near zero order
release profile, which is often difficult with matrix
formulations.
The
System Performance
Intellectual Property
The RubiERTTM
technology is covered by pending patent applications. Key Attributes of RubiERTTM
• Versatile with respect to the category of the
drug molecule
• Suitable with respect to drugs having different
doses
• Adaptability of the system for drugs with different
aqueous solubilities
• Possibility of achieving different release profiles
• Excipients employed are pharmacopoeial
• Conventional method of manufacture Benefits
• Better utilisation of the drug
• Reduction in frequency of dosing
• Better patient compliance
• Reduced adverse reactions
